Patent Number: 7,820,693

Title: 1-(2H)-isoquinolone derivative

Abstract: The present invention provides a compound having high antitumor activity, which is useful for therapeutic and preventive agents effective for proliferative diseases such as cancer; a production method thereof; an intermediate compound useful for such production; and a pharmaceutical composition comprising such a compound. The present invention provides a compound represented by the formula (1): ##STR00001## wherein X represents an aryl group or heteroaryl group which may be substituted, Cy represents a 4- to 7-membered monocyclic heterocyclic ring or a 8- to 10-membered condensed heterocyclic ring which may be substituted, and Z represents O, S, or NRa; or a prodrug thereof; or a pharmaceutically acceptable salt thereof; and a pharmaceutical and a pharmaceutical composition which comprise the compound.

Inventors: Hattori; Kazuo (Kamakura, JP), Niizuma; Satoshi (Kamakura, JP), Masubuchi; Miyako (Kamakura, JP), Koyama; Kohei (Kamakura, JP), Kondoh; Osamu (Kamakura, JP), Tsukaguchi; Toshiyuki (Kamakura, JP), Okada; Takehiro (Kamakura, JP)

Assignee: Chugai Seiyaku Kabushiki Kaisha

International Classification: A61K 31/47 (20060101); C07D 401/10 (20060101)

Expiration Date: 2018-10-26 0:00:00