Patent Number: 7,820,697

Title: Compositions and method for reducing TNF.alpha. levels

Abstract: 1-Oxo- and 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines substituted in the 4- and/or 7-position of the isoindoline ring and optionally further substituted in the 3-position of the 2,6-dioxopiperidine ring reduce the levels of inflammatory cytokines such as TNF.alpha. in a mammal. A typical embodiment is 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline.

Inventors: Man; Hon-Wah (Neshanic Station, NJ), Muller; George W. (Bridgewater, NJ)

Assignee: Celgene Corporation

International Classification: A61K 31/454 (20060101); C07D 403/04 (20060101)

Expiration Date: 2018-10-26 0:00:00