Patent Number: 7,820,704

Title: Substituted heteroaryl derivatives, compositions, and methods of use

Abstract: The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.

Inventors: Mjalli; Adnan M. M. (Jamestown, NC), Gaddam; Bapu R. (Greensboro, NC), Qabaja; Ghassan (High Point, NC), Subramanian; Govindan (High Point, NC), Zhu; Jeff (Greensboro, NC), Dankwardt; John (Westborough, MA), Arimilli; Murty N. (Oak Ridge, NC), Andrews; Robert C. (Jamestown, NC), Victory; Samuel (Oak Ridge, NC), Tian; Ye E. (Jamestown, NC)

Assignee: TransTech Pharma, Inc.

International Classification: A61K 31/427 (20060101); A61K 31/381 (20060101); C07D 277/38 (20060101); C07D 409/12 (20060101)

Expiration Date: 2018-10-26 0:00:00