Patent Number: 7,820,715

Title: Crystal comprising (2R)-2-propyloctanoic acid and amine

Abstract: Crystals comprising (2R)-2-propyloctoic acid and an amine which retain the pharmacological effect of (2R)-2-propyloctoic acid and can be safely used as a medicinal raw drug for peroral solid preparations. Of these crystals, the crystals especially with dibenzylamine are advantageous because not only the crystals themselves are useful as a medicinal raw drug but also use of the crystals as an intermediate can yield (2R)-2-propyloctoic acid having an optical purity exceeding 99.5% e.e., which has not been obtained hitherto.

Inventors: Hasegawa; Tomoyuki (Sakai, JP), Kawanaka; Yasufumi (Sakai, JP), Kasamatsu; Eiji (Sakai, JP)

Assignee: Ono Pharmaceutical Co., Ltd.

International Classification: A61K 31/205 (20060101); C07C 229/00 (20060101); C07B 57/00 (20060101)

Expiration Date: 2018-10-26 0:00:00