Patent Number: 7,820,791

Title: H.sup.+-gated ion channel

Abstract: The invention relates to an isolated or recombinant Na.sup.+/H.sup.+ exchanger comprising an isolated or recombinant Na.sup.+/H.sup.+ exchanger, particularly to the PBO-4 Na.sup.+/H.sup.+ exchanger. Also disclosed is an isolated or recombinant protein component of an H.sup.+-gated channel which can be affected by extracellular Ca.sup.2+ concentration. In particular, the invention relates to PBO-5 and/or PBO-8 and/or a H.sup.+-gated channel composed of PBO-5 and PBO-8. The invention relates to compounds isolated from a vertebrate organism, wherein said compounds comprise at least a part of a H.sup.+-gated channel or Na.sup.+/H.sup.+ exchanger. The invention also relates to a method for identifying a component of a H.sup.+-gated channel in a vertebrate organism.

Inventors: Jorgensen; Erik M. (Salt Lake City, UT), Beg; Asim A. (Ann Arbor, MI), Nix; Paola (Salt Lake City, UT)

Assignee: University of Utah Research Foundation

International Classification: C07K 14/00 (20060101)

Expiration Date: 2018-10-26 0:00:00