Patent Number: 7,820,798

Title: Tumor necrosis factor-gamma

Abstract: Human TNF-gamma-alpha and TNF-gamma-beta polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptides to inhibit cellular growth, for example in a tumor or cancer, for facilitating wound-healing, to provide resistance against infection, induce inflammatory activities, and stimulating the growth of certain cell types to treat diseases, for example restenosis. Also disclosed are diagnostic methods for detecting a mutation in the TNF-gamma-alpha and TNF-gamma-beta nucleic acid sequences or overexpression of the TNF-gamma-alpha and/or TNF-gamma-beta polypeptides. Antagonists against such polypeptides and their use as a therapeutic to treat cachexia, septic shock, cerebral malaria, inflammation, arthritis and graft-rejection are also disclosed.

Inventors: Yu; Guo-Liang (Berkeley, CA), Ni; Jian (Germantown, MD), Rosen; Craig A. (Laytonsville, MD), Zhang; Jun (San Diego, CA)

Assignee: Human Genome Sciences, Inc.

International Classification: C07K 16/28 (20060101); C07K 16/22 (20060101); C07K 16/46 (20060101); C12N 5/00 (20060101); C07K 16/18 (20060101); G01N 33/53 (20060101)

Expiration Date: 2018-10-26 0:00:00