Patent Number: 7,820,821

Title: Benzazole derivatives, compositions, and methods of use as aurora kinase inhibitors

Abstract: The present invention relates to compounds and methods from the treatment of cancer. The invention provides compounds that inhibit Aurora kinase, pharmaceutical compositions comprising compounds that inhibit Aurora kinase, and methods for the treatment of cancer using the compounds of the presentation invention or pharmaceutical compositions comprising compounds of the present invention.

Inventors: Mjalli; Adnan M. M. (Oak Ridge, NC), Grella; Brian S. (High Point, NC), Subramanian; Govindan (Bellemeade, NJ), Arimilli; Murty N. (Oak Ridge, NC), Gopalaswamy; Ramesh (Jamestown, NC), Andrews; Robert C. (Jamestown, NC), Davis; Stephen (Durham, NC), Guo; Xiaochuan (High Point, NC), Zhu; Jeff (High Point, NC)

Assignee: TransTech Pharma, Inc.

International Classification: A61K 31/496 (20060101); C07D 401/14 (20060101); C07D 403/14 (20060101)

Expiration Date: 2018-10-26 0:00:00