Patent Number: 7,824,491

Title: Method for crystallizing aurora 2 kinase catalytic domain polypeptide

Abstract: The present invention discloses nucleic acids that encode an active human Aurora 2 kinase catalytic domain. The present invention also discloses methods of growing X-ray diffractable crystals of polypeptides comprising the active human Aurora 2 kinase catalytic domain. The present invention further discloses a crystalline form of a catalytic domain of human Aurora 2 kinase. In addition, the present invention discloses methods of using the X-ray diffractable crystals of human Aurora 2 kinase in structure assisted drug design to identify compounds that can modulate the enzymatic activity of human Aurora 2 kinase.

Inventors: Fischmann; Thierry O. (Scotch Plains, NJ), Madison; Vincent S. (Ukiah, CA), Hruza; Alan William (Hackettstown, NJ), Reichert; Paul (Montville, NJ), Ramanathan; Lata (Cambridge, NJ), Sanden; David Paul (San Francisco, CA), Seghezzi; Wolfgang (Mountain View, CA)

Assignee: Schering Corp.

International Classification: C30B 28/06 (20060101); G01N 31/00 (20060101); C12N 9/12 (20060101)

Expiration Date: 2019-11-02 0:00:00