Patent Number: 7,824,675

Title: Use of an antibody that binds human tumor necrosis factor receptor-like 2

Abstract: The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.

Inventors: Ni; Jian (Germantown, MD), Rosen; Craig A. (Laytonsville, MD), Gentz; Reiner L. (Belo Horizonte, BR)

Assignee: Human Genome Sciences, Inc.

International Classification: A61K 39/00 (20060101); A61K 39/395 (20060101)

Expiration Date: 2019-11-02 0:00:00