Patent Number: 7,824,876

Title: Method for diagnosing acute coronary syndrome

Abstract: A bioaffinity assay for quantitative determination in a sample of free PAPP-A, defined as the pregnancy associated plasma protein A (PAPP-A) that is not complexed to the proform of major basic protein (proMBP), where free PAPP-A is determined either i) as a calculated difference between measured total PAPP-A and measured PAPP-A complexed to proMBP, or ii) by a direct bioaffinity assay measuring only free PAPP-A. Also disclosed is a method for diagnosing an acute coronary syndrome in a person by using as marker either free PAPP-A as such or a ratio free PAPP-A/total PAPP-A, free PAPP-A/PAPP-A complexed to proMBP, or PAPP-A complexed to proMBP/total PAPP-A.

Inventors: Qin; Qiu-Ping (Turku, FI), Pettersson; Kim (Turku, FI)

Assignee: Turun Yliopisto

International Classification: G01N 33/573 (20060101); G01N 33/538 (20060101); G01N 33/536 (20060101); G01N 33/543 (20060101)

Expiration Date: 2019-11-02 0:00:00