Patent Number: 7,825,100

Title: Specific GRP78 expression-inhibition RNAi sequence, medicine thereof and method thereof

Abstract: The present invention discloses a specific GRP78 expression-inhibition RNAi sequence, a medicine thereof and a method thereof, wherein an RNAi sequence 5'-AAGGATGGTTAATGATGCTGAGAA-3' complementary to GRP78 forms a special hair-pin structure inside cancer cells to specifically and effectively inhibit GRP78 expression and then inhibit the canceration process, including the growth, migration, invasion, and metastasis of cancer.

Inventors: Cheng; Ann-Joy (Linkou Shiang, TW), Chang; Joseph T. (Linkou Shiang, TW), Chiu; Ching-Chi (Daliao Shiang, TW)

Assignee: Chang Gung University

International Classification: A61K 48/00 (20060101); C12N 15/63 (20060101); C07H 21/02 (20060101); C07H 21/04 (20060101)

Expiration Date: 2019-11-02 0:00:00