Patent Number: 7,825,114

Title: Substituted aminopyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same

Abstract: The invention relates to substituted aminopyrazolopyridines according to the general formula (I): ##STR00001## in which A, B, D, E, R.sup.a, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and q are as defined in the claims, and salts thereof, to pharmaceutical compositions comprising said substituted aminopyrazolopyridines, to methods of preparing said substituted aminopyrazolopyridines as well as the use thereof for manufacturing a pharmaceutical composition for the treatment of diseases of dysregulated vascular growth or of diseases which are accompanied with dysregulated vascular growth, wherein the compounds effectively interfere with Tie2 signalling.

Inventors: Hartung; Ingo (Berlin, DE), Ince; Stuart (Berlin, DE), Kettschau; Georg (Berlin, DE), Thierauch; Karl-Heinz (Berlin, DE), Briem; Hans (Bremen, DE), Schwede; Wolfgang (Glienicke, DE), Laak Ter; Antonius M. (Berlin, DE)

Assignee: Bayer Schering Pharma AG

International Classification: A61K 31/5377 (20060101); A61K 31/437 (20060101); A61P 35/00 (20060101); A61P 27/02 (20060101); C07D 471/04 (20060101)

Expiration Date: 2019-11-02 0:00:00