Patent Number: 7,825,160

Title: (Biphenyl) carboxylic acids and derivatives thereof

Abstract: The present invention relates to compounds having the general formula (I) with the definitions of A, X, R.sub.1-R.sub.6 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of .gamma.-secretase activity.

Inventors: Wilson; Francis (Welwyn Garden City, GB), Reid; Alison (Cottenham, GB), Reader; Valerie (Linton, GB), Harrison; Richard John (Cambridge, GB), Sunose; Mihiro (Papisford, GB), Hernandez-Perni; Remedios (Stalybridge, GB), Major; Jeremy (Cambridge, GB), Boussard; Cyrille (Saffron Walden, GB), Smelt; Kathryn (London, GB), Taylor; Jess (Hertfordshire, GB), Leformal; Adeline (Saffron Walden, GB), Cansfield; Andrew (Harston, GB), Burckhardt; Svenja (Boxworth, GB)

Assignee: Cellzome Limited

International Classification: A01N 37/10 (20060101); C07C 62/00 (20060101); C07C 61/04 (20060101); C07C 61/16 (20060101); C07C 63/333 (20060101); A61K 31/19 (20060101); A01N 37/08 (20060101); A01N 53/00 (20060101); A61K 31/557 (20060101); C07C 63/00 (20060101); C07C 65/00 (20060101); C07C 63/33 (20060101)

Expiration Date: 2019-11-02 0:00:00