Patent Number: 7,825,235

Title: Modulation of diacylglycerol acyltransferase 2 expression

Abstract: Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of disease associated with expression of diacylglycerol acyltransferase 2 are provided.

Inventors: Bhanot; Sanjay (Carlsbad, CA), Dobie; Kenneth W. (Del Mar, CA), Yu; Xing-Xian (San Diego, CA), Monia; Brett P. (Encinitas, CA)

Assignee: Isis Pharmaceuticals, Inc.

International Classification: C07H 21/04 (20060101)

Expiration Date: 2019-11-02 0:00:00