Patent Number: 7,825,278

Title: Substituted enaminones, their derivatives and uses thereof

Abstract: The invention relates to substituted enaminones of Formula I and their derivatives and the discovery that these compounds modulate the effect of .gamma.-aminobutyric acid (GABA) on the GABA.sub.A receptor complex in a therapeutically relevant fashion and may be used to ameliorate CNS disorders amenable to modulation of the GABA.sub.A receptor complex. ##STR00001##

Inventors: Hogenkamp; Derk J. (Carlsbad, CA), Johnstone; Timothy B. C. (Costa Mesa, CA), Gee; Kelvin W. (Irvine, CA)

Assignee: The Regents of the University of California

International Classification: C07C 233/00 (20060101); A61K 31/36 (20060101); A61K 31/41 (20060101); A61K 31/24 (20060101); C07C 307/00 (20060101); C07C 229/00 (20060101); C07D 317/00 (20060101); C07D 261/00 (20060101); C07D 249/00 (20060101); A61K 31/165 (20060101); A61K 31/18 (20060101); A61K 31/42 (20060101)

Expiration Date: 2019-11-02 0:00:00