Patent Number: 7,826,982

Title: Method of identifying inhibitors using a 3-D structure of RAC-1 GTPASE

Abstract: The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

Inventors: Zheng; Yi (Cincinnati, OH), Nassar; Nicolas (Coram, NY), Skowronek; Karlheinz R. (Huntington Station, NY)

Assignee: Children's Hospital Medical Center

International Classification: G01N 31/00 (20060101); G06G 7/58 (20060101)

Expiration Date: 2019-11-02 0:00:00