Patent Number: 7,951,386

Title: Ehrlichia canis genes and vaccines

Abstract: This invention provides the sequence of 5,299 nucleotides from the E. canis genome. There are four proteins, ProA, ProB, MmpA, and a cytochrome oxidase homolog, as well as a partial lipoprotein signal peptidase homolog at the carboxy terminus, coded for in this cloned fragment. The antigenic properties of these proteins allow them to be used to create a vaccine. An embodiment of this invention includes the creation of a DNA vaccine, a recombinant vaccine, and a T cell epitope vaccine. Another embodiment of this invention includes the use of serological diagnosis techniques.

Inventors: Chang; Yung-Fu (Ithaca, NY)

Assignee: Cornell University

International Classification: C12N 15/00 (20060101); C07H 21/02 (20060101); A61K 49/00 (20060101); A61K 45/00 (20060101); A61K 48/00 (20060101)

Expiration Date: 2019-05-31 0:00:00