Patent Number: 7,956,201

Title: Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one

Abstract: The present invention relates to a process of the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula ##STR00001## by employing a dialkylmalonate of the formula ##STR00002## wherein R.sup.1b is lower alkyl, and the use of this process for the manufacture of DPP-IV inhibitors that are useful for the treatment and/or prophylaxis of diseases such as diabetes.

Inventors: Zutter; Ulrich (Basel, CH)

Assignee: Hoffman-La Roche Inc.

International Classification: C07D 455/06 (20060101); C07D 307/20 (20060101)

Expiration Date: 2019-06-07 0:00:00