Patent Number: 7,973,009

Title: Methods and compositions for the prevention and treatment of anemia

Abstract: Methods for increasing and maintaining hematocrit in a mammal comprising administering a hyperglycosylated analog of erythropoietin are disclosed. An analog may be administered less frequently than an equivalent molar amount of recombinant human erythropoietin to obtain a comparable target hematocrit and treat anemia. Alternatively, a lower molar amount of a hyperglycosylated analog may be administered to obtain a comparable target hematocrit and treat anemia. Also disclosed are new hyperglycosylated erythropoietin analogs, methods of production of the analogs, and compositions comprising the analogs.

Inventors: Egrie; Joan C. (Newbury Park, CA), Elliott; Steven G. (Newbury Park, CA), Browne; Jeffrey K. (Camarillo, CA), Sitney; Karen C. (Studio City, CA)

Assignee: Amgen Inc.

International Classification: A61K 38/18 (20060101); C07K 14/505 (20060101)

Expiration Date: 2019-07-05 0:00:00