Patent Number: 8,066,987

Title: Bacterial delivery of biologically active polypeptides

Abstract: The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonizing non-pathogenic Gram negative bacteria. Also provided by this invention are methods of treating or preventing diseases by administering colonizing Gram negative bacteria that express one or more biologically active polypeptides. The colonizing non-pathogenic Gram negative bacteria may be administered in pharmaceutical formulations.

Inventors: Moore; Robert John (Ascot Vale, AU), Rood; Julian Ian (Bentleigh, AU), Sheedy; Scott Andrew (North Geelong, AU)

Assignee: Commonwealth Scientific and Industrial Research Organisation

International Classification: A01N 63/00 (20060101)

Expiration Date: 2020-11-29 0:00:00