Patent Number: 8,067,202

Title: Bacterial superantigen vaccines

Abstract: The present invention relates to genetically attenuated superantigen toxin vaccines altered such that superantigen attributes are absent, however the superantigen is effectively recognized and an appropriate immune response is produced. The attenuated superantigen toxins are shown to protect animals against challenge with wild type toxin. Methods of producing and using the altered superantigen toxins are described.

Inventors: Ulrich; Robert G. (Frederick, MD), Olson; Mark A. (Gaithersburg, MD), Bavari; Sina (Dillsburg, PA)

Assignee: The United States of America as represented by the Secretary of the Army

International Classification: C12N 15/09 (20060101)

Expiration Date: 2020-11-29 0:00:00