Patent Number: 8,071,547

Title: Compositions of alpha-fetoprotein and inducers of apoptosis for the treatment of cancer

Abstract: The invention relates to novel compositions comprising alpha-fetoprotein (AFP) and methods for preventing, treating or inhibiting a malignant neoplasm expressing an alpha-fetoprotein receptor (AFPR) with or without multidrug resistance. Compositions comprising a non-covalent complex of an exogenous AFP, and at least one apoptosis-inducing agent selected from the group comprising mitochondrial membrane permeabilizing agents, mitochondrial pore opening inducing agents, ionophores, caspase 9 activators, caspase 3 activators and retinoids, are provided, wherein the at least one apoptosis-inducing agent reversibly binds to the exogenous AFP. The invention also provides for a process for butanol extraction of porcine alpha-fetoprotein obtained from blood and amniotic fluid extracted during early embryogenesis.

Inventors: Pak; Vladimir (Toronto, CA)

Assignee: Constab Pharmaceutical, Inc.

International Classification: A61K 38/00 (20060101); A01N 45/00 (20060101); A61P 35/00 (20060101)

Expiration Date: 2020-12-06 0:00:00