Patent Number: 8,088,916

Title: Hyaluronic acid-methotrexate conjugate

Abstract: An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.

Inventors: Ikeya; Hitoshi (Machida, JP), Morikawa; Tadashi (Machida, JP), Takahashi; Koichi (Machida, JP), Tamura; Tatsuya (Gotenba, JP), Okamachi; Akira (Susono, JP), Ishizawa; Takenori (Gotenba, JP), Sato; Haruhiko (Gotenba, JP), Higuchi; Yoshinobu (Gotenba, JP)

Assignee: Denki Kagaku Kogyo Kabushiki Kaisha

International Classification: C08B 37/00 (20060101); A01N 43/60 (20060101); A01N 43/04 (20060101)

Expiration Date: 2020-01-03 0:00:00