Patent Number: 8,088,968

Title: Transgenic animals for analyzing CYP3A4 cytochrome P450 gene regulation

Abstract: The invention relates to the generation of non-human transgenic animals comprising a reporter construct for producing a detectable amount of a reporter molecule operably linked to a transcriptional regulatory nucleic acid molecule from the human CYP3A4 gene located between the initiation of transcription site of the gene and a position located 13,000 nucleotides upstream from the site. The invention also relates to the use of these animals for determining the effect of a compound, particularly, but not exclusively, a xenobiotic or steroid, on the regulation of expression of the CYP3A4 gene in a human.

Inventors: Liddle; Christopher (Chatswood, AU), Goodwin; Bryan James (Morrisville, NC), Robertson; Graham (Sydney, AU)

Assignee: The University of Sydney

International Classification: G01N 33/00 (20060101); C12N 5/00 (20060101); A01K 67/027 (20060101); A01K 67/00 (20060101); C12N 15/11 (20060101)

Expiration Date: 2020-01-03 0:00:00