Patent Number: 8,298,529

Title: Compositions and method for epigenetic modification of nucleic acid sequences in vivo

Abstract: Demethylation of a methylated DNA sequence in a eukaryotic cell is described, utilizing a molecule that includes at least a first domain that exhibits a cytidine deaminase activity and at least a second domain that confers either a specific or non-specific DNA binding activity. The molecules of the invention are useful in somatic cell nuclear transfer and also in cancer therapy.

Inventors: Reik; Wolf (Cambridge, GB), Morgan; Hugh (Cambridge, GB), Chan; Chun-Fung (Hong Kong, HK)

Assignee: CellCentric Limited

International Classification: A61K 38/43 (20060101); C12N 9/88 (20060101)

Expiration Date: 2020-10-30 0:00:00