Patent Number: 8,299,106

Title: Compositions of kinase inhibitors and their use for treatment of cancer and other diseases related to kinases

Abstract: The present invention relates to novel thiazole-substituted indolin-2-ones as inhibitors of CSCPK and related kinases; to methods of inhibiting cancer stem cells by using a kinase inhibitor; to pharmaceutical compositions containing such compounds; and to methods of using such compounds in the treatment of a protein kinase related disorder in a mammal; and to processes of making such compounds and intermediates thereof.

Inventors: Li; Chiang Jia (Cambridge, MA), Liu; Ji-Feng (Winchester, MA), Li; Youzhi (Westwood, MA), Li; Wei (Wayland, MA), Rogoff; Harry (Wrentham, MA)

Assignee: Boston Biomedical, Inc.

International Classification: A01N 43/78 (20060101); A61K 31/425 (20060101)

Expiration Date: 2020-10-30 0:00:00