Patent Number: 8,299,252

Title: Pyrazolopyridine and pyrrolopyridine multikinase inhibitors

Abstract: It is intended to provide a compound represented by the formula (1): ##STR00001## [wherein Ar is an arylene group to be attached selected from the following formula (2): ##STR00002## (wherein * represents a binding site to a nitrogen atom and ** represents a binding site to T); T represents --(O).sub.n--R; R represents a C.sub.1-C.sub.6 alkyl group or the like; n represents 0 or 1; X represents O or the like; R.sup.2, R.sup.3 and R.sup.4 are independently selected from a hydrogen atom or C.sub.1-C.sub.3 alkyl; or R.sup.2 and R.sup.3 may join together with an urea structure containing the nitrogen atoms to which they bind to form a 5- or 6-membered heterocycle; Y represents CH or N], or a pharmaceutically acceptable salt thereof or a prodrug thereof and a pharmaceutical composition containing the same.

Inventors: Ozawa; Sawako (Kamakura, JP), Oikawa; Nobuhiro (Kamakura, JP), Mizuguchi; Eisaku (Kamakura, JP), Ebiike; Hirosato (Kamakura, JP), Watanabe; Fumio (Kamakura, JP), Morikami; Kenji (Kamakura, JP), Shimma; Nobuo (Kamakura, JP), Ishii; Nobuya (Kamakura, JP), Tsukaguchi; Toshiyuki (Kamakura, JP)

Assignee: Chugai Seiyaku Kabushiki Kaisha

International Classification: A61K 31/437 (20060101); C07D 471/04 (20060101)

Expiration Date: 2020-10-30 0:00:00