Patent Number: 8,303,945

Title: Mutants of interleukin-1 receptor antagonist

Abstract: The invention provides an isolated polypeptide comprising a variant amino acid sequence of SEQ ID NO: 1, or a fusion or derivative of said polypeptide, or a fusion of a said derivative thereof, wherein the polypeptide, fusion or derivative retains a biological activity of wild type IL-IRa. In one embodiment, the isolated polypeptide, fusion or derivative is or comprises a polypeptide variant of amino acid sequence SEQ ID NO: 1 comprising or consisting of substitutions at one or more of the following amino acid mutations of SEQ ID NO: 1: Q29K, P38Y, P38R, L42W, D47N, E52R, H54R, E90Y, Q129L, Q129N, M136N, M136D and Q149K. Also provided are pharmaceutical compositions of the above polypeptide, fusion or derivative, as well as uses of the same for treating a disease or condition capable of being treated by an agent which inhibits the function of IL-1 receptors.

Inventors: Dahlen; Eva Maria (Arlov, SE), Barchan; Karin Elisabeth (Kalgshamn, SE), Hojman; Patrick Thomas (Malmo, SE), Hager; Cecilia Ann-Christin Malmborg (Helsingborg, SE), Karlsson; Marie Asa Ingegerd (Lund, SE), Anderson; Mats Peter (Kavlinge, SE), Walse; Bjorn Ulrik (Lund, SE)

Assignee: Alligator Bioscience AB

International Classification: C07K 14/715 (20060101); A61K 38/19 (20060101)

Expiration Date: 2021-11-06 0:00:00