Patent Number: 8,303,947

Title: Inoculation of recombinant viral vectors for rapid pre-exposure prevention and post-exposure protection against alpha-virus-induced encephalitides

Abstract: This invention addresses how to rapidly prevent alphavirus-induced encephalitides before and after exposure to alphaviruses. The invention discloses a single dose administration of two types of recombinant viral vectors: one expressing interferon and another expressing the structural proteins of alphaviruses or a single dose administration of the recombinant viral vector co-expressing both interferon and the structural proteins of alphaviruses. This invention can be used to prevent humans from alphavirus-induced encephalitides in the event of a bioterrorism attack or biowarfare in which alphaviruses such as Venezuelan (VEEV), eastern (EEEV) and western (WEEV) equine encephalitis viruses are deliberately released to humans, a natural outbreak of alphaviruses, and an accidental exposure to alphaviruses in laboratory.

Inventors: Wu; Josh Qiaohua (Medicine Hat, CA), Nagata; Leslie P. (Medicine Hat, CA)

Assignee: Her Majesty the Queen in right of Canada, as represented the Minister of National Defence

International Classification: A01N 63/04 (20060101); C12N 15/79 (20060101)

Expiration Date: 2021-11-06 0:00:00