Patent Number: 8,303,963

Title: Methylated heparin-binding hemagglutinin recombinant mycobacterial antigen, preparation method and immunogenic compositions comprising same

Abstract: The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, the sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections.

Inventors: Pethe; Kevin (La Madeleine, FR), Menozzi; Franco (Hyon, BE), Locht; Camille (Brussels, BE)

Assignee: Institut Pasteur de Lille

International Classification: A61K 39/04 (20060101); A61K 49/00 (20060101); A61K 39/02 (20060101)

Expiration Date: 2021-11-06 0:00:00