Patent Number: 8,318,713

Title: Potentiation of cancer chemotherapy by 7-(2, 5-dihydro-4-imidazo [1, 2-A] pyridine-3-yl-2,5-Dioxo-1H-pyrrol-3-yl)-9-fluoro-1,2,3,4 tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo [3,2,1-jk] [1,4] benzodiazepine

Abstract: A method for treating gastric cancer, ovarian cancer, non-small cell lung cancer, or colorectal cancer in a patient is described, as well as pharmaceutical compositions comprising 7-(2,5-dihydro-4-imidazo[1,2-a]pyridine-3-yl-2,5-dioxo-IH-pyrrol-3-yl)-9-- fluoro-1,2,3,4-tetrahydro-2-(1-piperidinyl-carbonyl)-pyrrolo[3,2,1-jk][1,4- ]benzodiazepine, useful for the method and a process for preparing said compositions.

Inventors: Chedid; Marcio (Fishers, IN), Engler; Thomas Albert (Indianapolis, IN)

Assignee: Eli Lilly and Company

International Classification: A01N 43/00 (20060101); A61K 31/55 (20060101); A01N 43/62 (20060101); A61K 31/33 (20060101)

Expiration Date: 2021-11-27 0:00:00