Patent Number: 8,491,872

Title: Cinnamic acid-based oligomers and uses thereof

Abstract: Cinnamic acid-based oligomers and therapeutic uses thereof are provided. The oligomers are used as anti-inflammation agents, inhibitors of elastase and anti-oxidants, and in some cases (e.g. the treatment of lung disorders such as lung cancer) all three activities are simultaneously beneficial. Subsets of the oligomers (e.g. .beta.-O4 and .beta.-5 trimers and tetramers) are used as anticoagulants.

Inventors: Desai; Umesh R. (Glen Allen, VA), Henry; Brian L. (Pittsburgh, PA), Liang; Aiye (North Charleston, SC), Thakkar; Jay (Denver, CO), Mangrum; John B. (Richmond, VA), Filho; Ivo Torres (Glen Allen, VA), Spiess; Bruce D. (Manakin-Sabot, VA), Sakagami; Masahiro (Richmond, VA), Saluja; Bhawana (N. Bethesda, MD)

Assignee: Virginia Commonwealth University

International Classification: A61P 7/02 (20060101); C07D 307/80 (20060101); A61P 29/00 (20060101); A61P 11/00 (20060101); A61K 31/185 (20060101); A61K 31/343 (20060101); A61K 31/255 (20060101); C07C 305/24 (20060101); C07D 307/84 (20060101); C07D 407/14 (20060101)

Expiration Date: 2021-07-23 0:00:00