Patent Number: 8,491,886

Title: Viruses for the treatment of cellular proliferative disorders

Abstract: Methods for treating cell proliferative disorders by administering virus to proliferating cells having an activated Ras-pathway are disclosed. The virus is administered so that it ultimately directly contacts proliferating cells having an activated Ras-pathway. Proliferative disorders include but are not limited to neoplasms. The virus is selected from modified adenovirus, modified HSV, modified vaccinia virus and modified parapoxvirus orf virus. Also disclosed are methods for treating cell proliferative disorders by further administering an immunosuppressive agent.

Inventors: Coffey; Matthew C. (Calgary, CA), Thompson; Bradley G. (Calgary, CA)

Assignee: Oncolytics Biotech Inc.

International Classification: A61K 39/00 (20060101); A61K 38/00 (20060101)

Expiration Date: 2021-07-23 0:00:00