Patent Number: 8,492,090

Title: Gene expression profiling in primary ovarian serous papillary tumors and normal ovarian epithelium

Abstract: Provided herein are methods for treating ovarian serous papillary carcinoma by delivering Clostridium perfringens enterotoxins to ovarian tumor cells overexpressing claudin 3 or claudin 4 protein or by inhibiting the expression and function of tumor-associated calcium signal transducer 1 (TROP-1/Ep-CAM) gene or gene product. Also provided is a method of detecting ovarian serous papillary carcinoma by examining a tumor sample from the individual for gene or gene product expression levels within a group of genes and performing statistical analysis to determine those genes or gene products which are down-regulated compared to those in a normal individual.

Inventors: Santin; Alessandro D. (Orange, CT)

Assignee: Board of Trustees of the University of Arkansas

International Classification: C12Q 1/68 (20060101); C07H 21/02 (20060101); C07H 21/04 (20060101)

Expiration Date: 2021-07-23 0:00:00