Patent Number: 8,496,931

Title: Monoclonal antibodies against stromal derived factor-1 (SDF-1)

Abstract: The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.

Inventors: Pogue; Sarah L. (Fremont, CA), Korman; Alan J. (Piedmont, CA), Cardarelli; Josephine M. (San Carlos, CA), Srinivasan; Mohan (Cupertino, CA), Chen; Bingliang (Alameda, CA), Bell; Alasdair F. (Mountain View, CA)

Assignee: Medarex, Inc.

International Classification: A61K 39/395 (20060101)

Expiration Date: 2021-07-30 0:00:00