Patent Number: 8,497,299

Title: Compositions including quinonoid derivatives of cannabinoids for therapeutic use

Abstract: The present invention relates to cannabinoic quinone compounds, and especially to their medical use. In particular five cannabinoic quinones, designated HU-331, HU-336, HU-345, HU-395 and HU-396, are described as active agents in pharmaceutical compositions. These compounds and compositions thereof are intended for the treatment of inflammatory, infectious, auto-immune and particularly hyperproliferative disorders. Thus, the compounds of the invention may be used as anti-tumor agents, or for the treatment of cancer. Furthermore, three of these compounds, HU-345, HU-395 and HU-396, are novel cannabinoic quinones.

Inventors: Mechoulam; Raphael (Jerusalem, IL), Kogan; Natalya M. (Jerusalem, IL), Rabinowitz; Ruth (Jerusalem, IL), Schlesinger; Michael (Jerusalem, IL)

Assignee: Yissum Research Development Company of The Hebrew University of Jerusalem

International Classification: A61K 31/35 (20060101); C07D 311/80 (20060101)

Expiration Date: 2021-07-30 0:00:00