Patent Number: 8,507,011

Title: Method for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition prepared on-site

Abstract: A composition and method are described for suppressing or preventing fibrous adhesion formation using a multicomponent aqueous oxychlorine composition. Fibrous adhesions typically form during healing of tissue, for example following a surgical procedure. A multicomponent oxychlorine composition is provided for irrigating the tissue which minimizes post-surgical adhesion formation, the composition containing both chlorine dioxide and chlorite ion, and a complexion thereof. The chlorine dioxide level generally is in an effective range of ClO.sub.2 concentration from about 10 ppm to a maximum of about 110 ppm. In a preferred embodiment, a physiological composition is provided in a thickened form to increase retention in the area being treated. The composition is preferably based on a standard saline solution converted to the oxychlorine composition just prior to use by sequential addition of aqueous concentrates of a chlorite salt, a hypochlorite salt combined with a physiological buffer-producing salt of a multibasic acid, and an acidifying agent, optionally including a thickening agent.

Inventors: Kross; Robert D. (Bellmore, NY), Villanueva; Cleva (Colonia Anahuac, MX)

Assignee:

International Classification: A61K 33/14 (20060101); A61K 33/20 (20060101); A61L 2/18 (20060101); A61L 2/00 (20060101)

Expiration Date: 2021-08-13 0:00:00