Patent Number: 8,574,857

Title: Method and means for treatment of osteoarthritis

Abstract: The present invention relates to in vivo and in vitro methods, agents and compound screening assays for inducing anabolic stimulation of chondrocytes, including cartilage formation enhancing pharmaceutical compositions, and the use thereof in treating and/or preventing a disease involving a systemic or local decrease in mean cartilage thickness in a subject.

Inventors: Vandeghinste; Nick (Duffel, BE), Tomme; Peter Herwig Maria (Gent, BE), Michiels; Frits (Leiderdorp, NL), Ma; Libin (Oegstgeest, NL), Mille-Baker; Blandine (Oegstgeest, NL), van Es; Helmuth G. G. (Haarlem, NL)

Assignee: Galapagos N.V.

International Classification: G01N 33/53 (20060101); C12Q 1/68 (20060101)

Expiration Date: 1/05/12017