Patent Number: 8,575,094

Title: Use of type-B lantibiotic-based compounds having antimicrobial activity

Abstract: A method for the treatment or prophylaxis of a microbial infection of the lower intestine or colon in a subject is described, wherein the method comprises administration to the subject of a type-B lantibiotic, wherein the type-B lantibiotic may include compounds selected from the group consisting of mersacidin, actagardine, plantaricin, planosporicin, ruminococcin, antibiotic 10789, michiganin and haloduracin, and derivatives and variants thereof.

Inventors: Wadman; Sjoerd Nicolaas (Welwyn Garden City, GB), Dawson; Michael John (Welwyn Garden City, GB), Bargallo; Jesus Cortes (Welwyn Garden City, GB)

Assignee: Novacta Biosystems Limited

International Classification: A61K 38/12 (20060101); C07K 7/64 (20060101)

Expiration Date: 1/05/12017