Patent Number: 8,575,103

Title: Peptides and methods for inhibiting G alpha protein signaling

Abstract: Permeable Switch Region I and II peptides in the range of 9 to 25 amino acid residues in length are provided for specifically inhibiting signaling through G.alpha. subunits. In addition, compositions and methods for inhibiting platelet aggregation and .alpha..sub.11b.beta..sub.3 integrin activation using the Switch Region I and II peptides are provided.

Inventors: Le Breton; Guy (Oak Park, IL), Huang; Jin-Sheng (Oak Park, IL), Srinivasan; Subhashini (Chicago, IL), Khasawneh; Fadi T. (Rancho Cucamonga, CA)

Assignee: The Board of Trustees of the University of Illinois

International Classification: A61K 38/00 (20060101); C07K 9/00 (20060101); C07K 7/06 (20060101); C07K 7/08 (20060101); A61K 38/08 (20060101); A61P 7/02 (20060101)

Expiration Date: 1/05/12017