Patent Number: 8,575,114

Title: SGLT-2 inhibitors, methods of making them, and uses thereof

Abstract: The present invention relates to compounds which are inhibitors of sodium dependent glucose co-transporter-2 (SGLT-2). These compounds are used in the treatment of various disorders, including diabetes, impaired glucose tolerance, insulin resistance, retinopathy, nephropathy, neuropathy, cataracts, hyperglycemia, hyperinsulinemia, hyperchlolesterolemia, elevated blood level of free fatty acids or glycerol, hyperlipidemia, hypertriglyceridemia, obesity, wound healing, tissue ischemia, atherosclerosis, and hypertension. These compounds and compositions are also useful for treating and preventing kidney stones, hyperuricemia, gout, and hyponatremia. Methods of making these compounds are also described in the present invention.

Inventors: Liu; Shuang (Schenectady, NY), Guo; Cheng (Schenectady, NY)

Assignee: Albany Molecular Research, Inc.

International Classification: A01N 43/04 (20060101); C07H 5/06 (20060101); C07H 5/04 (20060101); A61K 31/70 (20060101)

Expiration Date: 1/05/12017