Patent Number: 8,575,144

Title: Beta-lactamase inhibitory compounds

Abstract: Inhibitors of the enzyme beta-lactamase are provided comprising compounds of formula (II) ##STR00001## wherein R.sup.1 or R.sup.2 is a pyridyl group and R.sup.5 is a group of formula ##STR00002## The compounds are adapted to inhibit beta-lactamase as produced by beta-lactam resistant bacterial strains. Methods of treatment of beta-lactam resistant bacterial infections in patients are provided.

Inventors: Buynak; John D. (Dallas, TX), Sheri; Anjaneyulu (Woburn, MA), Pagadala; Sundar Ram Reddy (Dallas, TX)

Assignee: Southern Methodist University

International Classification: A61K 31/545 (20060101); C07D 501/14 (20060101); A61K 31/546 (20060101)

Expiration Date: 1/05/12017