Patent Number: 8,575,156

Title: Cyclic inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1

Abstract: Disclosed are compounds represented by Formula (I): ##STR00001## or pharmaceutically acceptable salts, enantiomers or diastereomers thereof. Also disclosed are pharmaceutical compositions comprising the compounds of Formula (I) or pharmaceutically acceptable salts, enantiomers or diastereomers thereof and methods of inhibiting 11.beta.-HSD1 activity comprising the step of administering to a mammal in need of such treatment an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof. Values for the variables in Formula (I) are defined herein.

Inventors: Claremon; David A. (Maple Glen, PA), He; Wei (Audubon, PA), McGeehan; Gerard (Garnet Valley, PA), Singh; Suresh B. (Kendall Park, NJ), Tice; Colin M. (Ambler, PA), Xu; Zhenrong (Horsham, PA), Ye; Yuanjie (Ambler, PA), Zhao; Wei (Eagleville, PA), Zhuang; Linghang (Chalfont, PA), Cacatian; Salvacion (Blue Bell, PA), Leftheris; Katerina (Skillman, NJ)

Assignee: Vitae Pharmaceuticals, Inc.

International Classification: C07D 413/10 (20060101); C07D 413/04 (20060101); A61K 31/541 (20060101); A61K 31/5377 (20060101); A61K 31/675 (20060101); C07D 241/04 (20060101)

Expiration Date: 1/05/12017