Patent Number: 8,575,160

Title: Imidazole derivatives as aldosterone synthase inhibitors

Abstract: The present invention provides a compound of formula (I) or pharmaceutically acceptable salt thereof, wherein the variables R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.7 and p are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. ##STR00001##

Inventors: Sun; Robert (Natick, MA), Monovich; Lauren G. (Belmont, MA), Chamoin; Sylvie (Saint Louis, FR), Westbrook; John (Woodbridge, CT)

Assignee: Novartis AG

International Classification: C07D 487/04 (20060101); A61K 31/4188 (20060101); A61K 31/428 (20060101)

Expiration Date: 1/05/12017