Patent Number: 8,575,178

Title: Isothiazolo-pyrimidinedione derivatives as TRPA1 modulators

Abstract: The present invention is related to novel isothiazolo[3,4-d]pyrimidinedione and isothiazolo[5,4-d]pyrimidinedione derivatives as TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds described herein are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1). Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. ##STR00001##

Inventors: Kumar; Sukeerthi (Navi Mumbai, IN), Thomas; Abraham (Navi Mumbai, IN), Margal; Sanjay (Navi Mumbai, IN), Khairatkar-Joshi; Neelima (Thane, IN), Mukhopadhyay; Indranil (Navi Mumbai, IN)

Assignee: Glenmark Pharmaceuticals S.A.

International Classification: A01N 43/90 (20060101); C07D 487/00 (20060101); C07D 471/00 (20060101); A61K 31/519 (20060101)

Expiration Date: 1/05/12017