Patent Number: 8,575,186

Title: Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT.sub.6) modulators and uses thereof

Abstract: The present invention relates to epiminocycloalkyl[b]indole derivatives as serotonin sub-type 6 (5-HT.sub.6) modulators, pharmaceutical compositions including these compounds, and methods of preparation and use thereof. These compounds are useful in the treatment of central nervous system disorders including obesity, metabolic syndrome, cognition, and schizophrenia. The subject compounds have the structure of formula (I) ##STR00001## with the substituents being described herein.

Inventors: Guzzo; Peter R. (Niskayuna, NY), Henderson; Alan J. (Albany, NY), Nacro; Kassoum (Albany, NY), Isherwood; Matthew L. (Delmar, NY), Ghosh; Animesh (Singapore, SG), Xiang; Kai (Singapore, SG)

Assignee: Albany Molecular Research, Inc.

International Classification: A61K 31/506 (20060101); A61P 3/00 (20060101); A61P 25/18 (20060101); A61P 25/28 (20060101); A61P 25/00 (20060101); A61P 3/10 (20060101); A61P 3/04 (20060101); C07D 471/18 (20060101); A61K 31/439 (20060101)

Expiration Date: 1/05/12017