Patent Number: 8,575,197

Title: Pyrolinone derivative and pharmaceutical composition comprising the same

Abstract: The present invention provides a novel P2X.sub.3 and/or P2X.sub.2/.sub.3 receptor antagonist. A compound represented by the formula (I): ##STR00001## wherein Z.sup.1 is optionally protected hydroxy, etc.; Z.sup.2 is --C(.dbd.O)--, etc.; Z.sup.3a and Z.sup.3b are taken together .dbd.O or .dbd.S; t is an integer of 0 to 4; R.sup.4a and R.sup.4b are each independently, hydrogen or substituted or unsubstituted lower alkyl, etc.; m and n are each independently an integer of 0 to 2; k is an integer of 0 or 1; Ring A is an aromatic carbocyclic ring or a heterocyclic ring, etc.; B is aromatic carbocyclic ring-diyl or heterocyclic ring-diyl, etc.; R.sup.1a and R.sup.1b are each independently halogen, hydroxy, substituted or unsubstituted lower alkyl, etc.; R.sup.2 is substituted or unsubstituted alkyl, etc.; R.sup.3 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; or its pharmaceutically acceptable salt, or a solvate thereof is provided.

Inventors: Kai; Hiroyuki (Osaka, JP), Taoda; Yoshiyuki (Osaka, JP), Endoh; Takeshi (Osaka, JP), Asahi; Kentaro (Osaka, JP), Tobinaga; Hiroyuki (Osaka, JP)

Assignee: Shionogi & Co., Ltd.

International Classification: A61K 31/4418 (20060101); A61K 31/4245 (20060101); C07D 401/04 (20060101); C07D 413/14 (20060101); C07D 403/14 (20060101); C07D 409/10 (20060101); C07D 261/08 (20060101); C07D 271/06 (20060101); C07D 207/38 (20060101); A61K 31/4025 (20060101); A61K 31/402 (20060101); A61K 31/422 (20060101); A61K 31/4439 (20060101); A61K 31/443 (20060101)

Expiration Date: 1/05/12017