Patent Number: 8,575,318

Title: Hepatocyte growth factor (HGF) binding proteins

Abstract: The present invention provides a family of binding proteins that bind and neutralize the activity of hepatocyte growth factor (HGF), in particular human HGF. The binding proteins can be used as diagnostic and/or therapeutic agents. With regard to their therapeutic activity, the binding proteins can be used to treat certain HGF responsive disorders, for example, certain HGF responsive tumors.

Inventors: Han; May (Brookline, MA), Wright; S. Kirk (Waltham, MA), Winston, Jr.; William M. (Marlborough, MA), Breault; Lyne (Roslindale, MA), Lin; Jie (West Roxbury, MA), Etemad-Gilbertson; Bijan (Jamaica Plain, MA), Knuehl; Christine (Natick, MA), Gyuris; Jeno (Lincoln, MA)

Assignee: AVEO Pharmaceuticals, Inc.

International Classification: C07K 16/24 (20060101); C07K 16/00 (20060101)

Expiration Date: 1/05/12017