Patent Number: 8,575,338

Title: Pyrimidine, pyridine and triazine derivatives as maxi-K channel openers

Abstract: A compound of formula (A); wherein ring A is an aromatic ring or a heteroaromatic ring; R.sup.1 is independently halogen, cyano, etc., each of X.sup.1, X.sup.2 and X.sup.3 is CR.sup.2 or nitrogen, R.sup.2 is independently hydrogens, etc., n is 0, 1, 2, 3 or 4; -D-Y is --O--CH.sub.2COOH, etc, and G is a substituted amino, a substituted heterocyclic group, etc, or a pharmaceutical acceptable salt thereof, has activities of opening BK channels. ##STR00001##

Inventors: Tsuzuki; Yasuyuki (Osaka, JP), Hirai; Miki (Osaka, JP)

Assignee: Mitsubishi Tanabe Pharma Corporation

International Classification: C07D 239/47 (20060101); C07D 239/34 (20060101); C07D 401/04 (20060101); C07D 403/04 (20060101); A61P 11/06 (20060101); A61P 13/10 (20060101); A61K 31/506 (20060101); C07D 403/14 (20060101); C07D 239/46 (20060101); C07D 401/14 (20060101)

Expiration Date: 1/05/12017