Patent Number: 8,575,340

Title: Purine derivatives and their pharmaceutical uses

Abstract: The present invention relates to compounds of formula (I): ##STR00001## wherein; R.sup.1 represents hydrogen or C.sub.1-3alkyl; n is an integer having a value of 1 to 5; X represents O or NH; Y represents C or N; or a pharmaceutically acceptable salt thereof, have been shown to be inducers of human interferon and may possess an improved profile with respect to known inducers of human interferon, for example enhanced potency. The compounds of the invention may therefore be useful in the treatment of various disorders, in particular the treatment of infectious diseases, cancer, allergic diseases and other inflammatory conditions, and their use as vaccine adjuvants.

Inventors: Bazin-Lee; Helene (Hamilton, MT), Coe; Diane Mary (Stevenage, GB), Johnson; David A. (Hamilton, MT), Mitchell; Charlotte Jane (Stevenage, GB)

Assignee: GlaxoSmithKline LLC

International Classification: A61K 31/52 (20060101); A61P 37/04 (20060101); A61P 11/06 (20060101); A61P 29/00 (20060101); A61P 35/00 (20060101); A61P 31/00 (20060101); C07D 473/18 (20060101); A61P 37/08 (20060101)

Expiration Date: 1/05/12017